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A potent inhibitor of Aurora A kinase (IC50 = 42 nM); selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively)
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MW 517.4 Da, Purity >98%. Type II topoisomerase inhibitor (IC₅₀ = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An IRAK4 inhibitor (IC50 = 35 nM); selective for IRAK4 over JNK1 and JNK2 at 10 µM; prevents increases in TNF-α and IL-12p40 levels in M. bovis-infected THP-1 cells at 1 µM
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A PDE4B inhibitor (IC50 = 140 nM); selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM; inhibits the activity of PDE4C1, PDE3B, 5-HT2C, and σ2 receptor by >50% activity at 10 µM; decreases LPS- or Pam3Cys-induced TNF-α production in mouse BMDMs at 1 µM; reduces cocaine self-administration and the progressive ratio breakpoint in mice at 5 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More